Bio: Dr. Paul Talalay, M.D.
Professor of Pharmacology, Johns Hopkins University School of Medicine
Paul Talalay, M.D., is the John Jacob Abel Distinguished Service
Professor of Pharmacology and Director of the Laboratory for Molecular
Sciences at Johns Hopkins
University School of Medicine in Baltimore.
He also is the founder of The Brassica Chemoprotection Laboratory, which
is dedicated to studying edible plants that induce protective enzyme
activity in the body and may help prevent cancer development.
Dr. Talalay has devoted his career to cancer research, focusing his
efforts on achieving early protection against cell damage. A pioneer in
the field of chemoprotective research strategies, Dr. Talalay and his
colleagues devised simple cell culture methods for detecting
phytochemicals which appear to boost enzymes that detoxify carcinogens
in the body. This work led to the isolation of sulforaphane (found in
broccoli) as a potent inducer of detoxifying phase 2 enzymes. These
findings, published in the Proceedings of the National Academy of
Sciences USA (1992), attracted worldwide attention as a major
breakthrough in understanding the potential link between cruciferous
vegetable consumption and reduced cancer risk.
Dr. Talalay has published more than 300 papers in international
scientific journals, and he holds one of the first lifetime
Professorships of the American Cancer Society. He is a member of the
National Academy of Sciences of the United States and the American
Philosophical Society, and is a Fellow of the American Academy of Arts
and Sciences.
The M.D.- Ph.D. Student Library at Johns Hopkins University is named
in Dr. Talalay's honor.
Dr. Talalay holds a degree in biophysics from the Massachusetts
Institute of Technology and a medical degree from Yale University. He
received an honorary Doctor of Science degree from Acadia University in
Halifax, Nova Scotia.
Contact Information
Dr. Paul Talalay receives mail at:
Department of Pharmacology
Johns Hopkins University School of Medicine
Wood Basic Science Building, Room 406
725 North Wolfe Street
Baltimore, Maryland 21205
Email: PTalalay@jhmi.edu
Patents
- US 5,411,986: Chemoprotective isothiocyanates
- US 5,968,505: Cancer chemoprotective food products
- US 5,968,567: Method of preparing a food product from cruciferous sprouts
- US 5,725,895: Method of preparing a food product from cruciferous seeds
- US 6,242,018: Cancer Chemoprotective food products
- US 6,177,122: Cancer Chemoprotective food products
Some Related Papers
- Sulforaphane inhibits
extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and
prevents benzo[a]pyrene-induced stomach tumors
- Proc. Natl. Acad. Sci. USA, Vol. 99, Issue 11,
pp. 7610-7615, May 28, 2002
- Powerful
and prolonged protection of human retinal pigment epithelial cells,
keratinocytes, and mouse leukemia cells against oxidative damage:
the indirect antioxidant effects of sulforaphane.
- Proc. Natl. Acad. Sci. USA, Vol. 98, Issue 26,
pp. 15221-15226, December 18, 2001
- Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
- Proc Natl Acad Sci USA, Vol. 98, Issue 6, 3410-3415, March 13, 2001
- Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
- Proc Natl Acad Sci USA, Vol. 98, Issue 6, 3404-3409, March 13, 2001
- The War Against Cancer: New Hope,
- Proceedings of the American Philosophical Society, March 1999, Vol. 143(1), pp. 52-72., Talalay, Paul.
- Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
- Food Chem Toxicol 1999 Sep-Oct;37(9-10):973-9
- Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
- Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 10367-10372, September 16, 1997
- Electrophile and Antioxidant Regulation of Enzymes that Detoxify Carcinogens
- Proc Natl Acad Sci USA 1995 Sep 12;92(19):8965-9
- Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates
- Proc Natl Acad Sci USA 1994 Apr 12;91(8):3147-50
- Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens
- Proc Natl Acad Sci USA 1993 Apr 1;90(7):2965-9
- A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure
- Proc Natl Acad Sci USA 1992 Mar 15;89(6):2399-403
- Rapid Detection of Inducers of Enzymes that Protect Against Carcinogens
- Proc Natl Acad Sci USA 1992 Mar 15;89(6):2394-8
- Chemoprotection against cancer by phase 2 enzyme induction.
- Toxicol Lett 1995 Dec;82-83:173-9
